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Publications from Funding Period 1 Publications from Funding Period 2 Publications from Funding Period 3

Guidelines for Acknowledgement & Publications

Botanical Dietary Supplements Research Center standard acknowledgment statement for investigator use when submitting manuscripts, abstracts, etc.

Use this descriptive statement as part of a submission: 

Acknowledgement

This publication was supported by the National Center For Complementary & Integrative Health and the Office of Dietary Supplements of the National Institutes of Health under Award Number P50AT002776 which funds the Botanical Dietary Supplements Research Center of Pennington Biomedical Research Center and the Department of Plant Biology and Pathology in the School of Environmental and Biological Sciences (SEBS) of Rutgers University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 

Publications from Funding Period 1

Links to free full-text articles in PubMed Central or through the Journal website are provided when available.

  1. Ribnicky DM, Pouley A, O’Neal J, Wnorowski G, Malek DE, Jager R, Raskin I. Toxicological evaluation of the ethanolic extract of Artemisia dracunculus L. for use as a dietary supplement and in functional foods. Food Chem Toxicol 2004;43(4):585-598. Accepted prior to April 7, 2008
  2. Logendra S, Ribnicky DM, Yang H, Poulev A, Ma J, Kennelly EJ, Raskin I. Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry 2006;67:1539-1546. Accepted prior to April 7, 2008
  3. Dey M, Ribnicky DM, Kurmukov AG, Raskin I. In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate. J Pharm Exp Ther 2006;317:326-333. Accepted prior to April 7, 2008 - Free Full-text from Journal
  4. Ribnicky DM, Poulev A, Watford M, Cefalu WT, Raskin I. Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine 2006;13:550-557. Accepted prior to April 7, 2008
  5. Keenan MJ, Zhou J, McCutcheon KL, Raggio AM, Bateman HG, Todd E, Jones CK, Tulley RT, Melton S, Martin RJ, Hegsted M. Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat. Obesity (Silver Spring). 2006 Sep;14(9):1523-1534 - Free Full-text from Journal
  6. Govorko D, Logendra S, Wang Y, Ribnicky DM, Poulev A, Cefalu WT, Raskin I. Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab 2007;293(6):E1503-E1510. Accepted prior to April 7, 2008 - Free Full-text from Journal
  7. Elo B, Villano CM, Govorko D, White L. Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase (PEPCK) as a marker for exposure to anti-diabetic compounds. J Mol Endocrinol 2007;38(4):433-440. Accepted prior to April 7, 2008 - Free Full-text from Journal
  8. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol 2007;3:360-366. Accepted prior to April 7, 2008
  9. Ma J, Dey M, Yang H, Poulev A, Pouleva R, Dorn R, Lipsky PE, Kennelly EJ, Raskin I. Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry 2007;68:1172-1178. Accepted prior to April 7, 2008
  10. Brinker AM, Ma J, Lipsky PE, Raskin I. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 2007;68:732-776. PMCID:  PMC3867260
  11. Wang ZQ, Zuberi AR, Zhang XH, Macgowan J, Qin J, Ye X, Son L, Wu Q, Lian K, Cefalu WT. Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet. Metabolism 2007 Dec 56;(12):1635-1642. PMCID: PMC2730183
  12. Okunji C, Komarnytsky S, Fear G, Poulev A, Ribnicky DM, Awachie PI, Ito Y, Raskin I. 2007. Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography. J Chromatogr 2007;1151:45-50. Accepted prior to April 7, 2008
  13. Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B, Lefevre M, York D, Ravussin E, Berthoud HR, McGuinness O, Cefalu WT, Ye J. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol Endocrinol Metab 2007 Jan;292(1):E84-91. Accepted prior to April 7, 2008 - Free Full-text from Journal
  14. Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 2008;294:E148-E156. PMCID: PMC2464622
  15. Burns Kraft TF, Dey M, Rogers RB, Ribnicky DM, Gipp DM, Cefalu WT, Raskin I, Lila MA. Phytochemical composition and metabolic performance enhancing activity of dietary berries traditionally used by Native North Americans. J Agric Food Chem 2008;Feb 13 56(3):654-660. PMCID: PMC2792121
  16. Ribnicky DM, Poulev A, Schmidt B, Cefalu WT, Raskin I. Evaluation of botanicals for improving human health. Am J Clin Nutr 2008;87(2):472S-475S. Accepted prior to April 7, 2008 - Free Full-text from Journal
  17. Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, Van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutr 2008;87(2):476S-480S. PMCID: PMC2715852
  18. Cefalu WT, Ye J, Zuberi A, Ribnicky DM, Raskin I, Liu Z, Wang ZQ, Brantley PJ, Howard L, Lefevre M. Botanicals and the metabolic syndrome. Am J Clin Nutr 2008;87(2):481S-487S. - Free Full-text from Journal
  19. Cefalu WT, Brantley PJ. Botanicals and cardiometabolic risk: positioning science to address the hype. Metabolism 2008;57(7 Suppl 1):S1-2. PMCID: PMC3838890
  20. Schmidt B, Ribnicky DM, Poulev A, Logendra S, Cefalu WT, Raskin I. A natural history of botanical therapeutics. Metabolism 2008;57(7 Suppl 1):S3-S9. PMCID: PMC2981029
  21. Zuberi AR. Strategies for assessment of botanical action on metabolic syndrome in the mouse and evidence for a genotype-specific effect of Russian tarragon in the regulation of insulin sensitivity. Metabolism 2008;57(7 Suppl 1):S10-15. PMCID: PMC2504519
  22. Kirk H, Cefalu WT, Ribnicky DM, Liu Z, Eilertsen KJ. Botanicals as epigenetic modulators for mechanisms contributing to development of Metabolic Syndrome. Metabolism 2008;57(7 Suppl 1):S16-23. Accepted prior to April 7, 2008
  23. Floyd EZ, Wang ZQ, Kilroy G, Cefalu WT. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism 2008;57(7 Suppl 1):S32-38. PMCID: PMC2585986
  24. Stewart LK, Soileau JL, Ribnicky DM, Wang ZQ, Raskin I, Poulev A, Majewski M, Cefalu WT, Gettys TW. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism 2008;57(7 Suppl 1):S39-46. PMCID: PMC2596873
  25. Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Cefalu WT, Ye J. Effect of shilianhua extract and its fractions on obesity. Metabolism 2008;57(7 Suppl 1):S47-51. PMCID: PMC2504524
  26. Lefevre M, Wiles JE, Zhang X, Howard LR, Gupta S, Smith AA, Ju ZY, Delany JP. Gene expression microarray analysis of the effects of grape anthocyanins in mice: a test of an hypothesis-generating paradigm. Metabolism 2008;57(7 Suppl 1):S52-S57. PMCID: PMC2577880
  27. Wang ZQ, Zhang X, Ribnicky DM, Raskin I, Cefalu WT. Bioactives of Artemisia dracunculus L. enhance cellular insulin signaling in primary human skeletal muscle culture. Metabolism 2008;57(7 Suppl 1):S58-S64.  PMCID: PMC2981033
  28. Ma J, Schmidt BM, Poulev A, Raskin I. Determination of tripdiolide in root extracts of Tripterygium wilfordii by solid phase extraction and reversed phase high performance liquid chromatography. Phytochem Anal 2008;19(4):348-352. PMCID: PMC4041272
  29. Ye J. Botanical Treatments for Diabetes and Obesity. Endocr Metab Immune Disord Drug Targets 2008;8:77. (Editorial)
  30. Cefalu WT, Ye J, Wang Z. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. In the "Hot Topics" issue on “Botanical Treatments for Diabetes and Obesity”. Endocr Metab Immune Disord Drug Targets 2008 8:78-81. (Review article) Accepted prior to April 7, 2008
  31. Yin J, Zhang H, Ye J. Traditional Chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets 2008;8:99-111. (Review article) PMCID: PMC2467395
  32. Liu Z. Preparation of botanical samples for biomedical research. In the "Hot Topics" issue on “Botanical Treatments for Diabetes and Obesity”. Endocr Metab Immune Disord Drug Targets 2008;8(2):112-121. PMCID: PMC3936020
  33. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57:712-717. PMCID: PMC2410097
  34. Cheng DM, Yousef GG, Grace MH, Rogers RB, Gorelick-Feldman J, Raskin I, Lila MA. In vitro production of metabolism-enhancing phytoecdysteroids from Ajuga turkestanica. Plant Cell Tissue Organ Cult 2008;93:73-83. Accepted prior to April 7, 2008
  35. Dushenkov V, Raskin I. New strategy for the search of natural biologically active substances. Russ J Plant Physiol 2008;55: 564-567. PMCID: PMC2600474
  36. Gorelick-Feldman J, MacLean D, Ilic N, Poulev A, Lila MA, Cheng D, Raskin I. Phytoecdysteroids increase protein synthesis in skeletal muscle cells. J Agric Food Chem 2008;56:3532-3537. Accepted prior to April 7, 2008
  37. Grace MH, Cheng DM, Raskin I, Lila MA. Neo-clerodane diterpenes from Ajuga turkestanica. Phytochem Lett 2008;1:81-84. PMCID: PMC2782872
  38. Dey M, Ripoll C, Pouleva R, Dorn R, Aranovich I, Zaurov DE, Kurmukov AG, Eliseyeva MR, Belolipov IV, Akimaliev A, Sodonbekov I, Akimaliev DA, Lila MA, Raskin I. Plant extracts from Central Asia showing antiinflammatory activities in gene expression assays. Phytother Res 2008;22:929-934. Accepted prior to April 7, 2008
  39. Dey M, Belolopiv I, Zakirov S, Akimaliev A, Akimaliev J, Sodonbekov I, Raskin I. Anti-inflammatory botanicals: a case study of genetic screens as part of a pharmacogenomic approach. In: Phytochemicals: Aging and Health (Meskin MS, et al, eds). Taylor and Francis/CRC Press, Boca Raton, FL, 2008:77-87. Book chapter.
  40. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther 2008;10(5):405-411. PMCID: PMC2753428
  41. Zhou J, Martin RJ, Tulley RT, Raggio AM, McCutcheon KL, Shen L, Danna SC, Tripathy S, Hegsted M, Keenan MJ. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab 2008 Nov;295(5):E1160-1166. PMCID: PMC2584810
  42. Zhou J, Martin RJ, Tulley RT, Raggio AM, Shen L, Lissy E, McCutcheon K, Keenan MJ. Failure to ferment dietary resistant starch in specific mouse models of obesity results in no body fat loss. J Agric Food Chem 2009 Oct 14;57(19):8844-8851. PMCID: PMC2766351 [Available on 2010/10/14]
  43. Ribnicky DM, Kuhn P, Poulev A, Logendra S, Zuberi A, Cefalu WT, Raskin I. Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. Int J Pharm 2009;370(1-2):87-92. PMCID: PMC3130197
  44. Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009;58 (7):1509-1517. PMCID: PMC2699871 [Available on 2010/7/1] - Free Full-text article from Journal
  45. Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I. 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 2009;296:E433-E439. PMCID: PMC2660145
  46. Grace M, Yousef GG, Kurmukov A, Raskin I, Lila MA. A. Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. Nat Prod Commun 2009;4:1053-1058. PMCID: PMC3815471
  47. Grace MH, Ribnicky DM, Kuhn P, Poulev A, Logendra S, Yousef GG, Raskin I, Lila MA. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 2009;16:406-415. PMCID: PMC2718544
  48. Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Ye J. Shilianhua extract inhibits GSK-3{beta} and promotes glucose metabolism. Am J Physiol Endocrinol Metab 2009;296:E1275-E1280. PMCID: PMC2692393
  49. Ye J, Yin J. Management of Insulin Resistance with Chinese Herbs. In: Handbook of Nutrition in the Aged, 4th edition (Watson RR, ed). Taylor & Francis/CRC Press, Boca Raton, FL, 2009;249-266. Book chapter.
  50. Stewart LK, Wang Z, Ribnicky DM, Soileau JL, Cefalu WT, Gettys TW. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of dietinduced obesity. Diabetologia 2009 Mar;52(3):514-523. PMCID: PMC2758024
  51. Amini ZJ, Boyd B, Doucet JA, Ribnicky DM, Stephens JM. St. John's Wort inhibits adipocyte differentiation and induces insulin resistance in adipocytes. Biochem Biophys Res Commun 2009;388:146–149. PMCID: PMC3019118
  52. Cefalu WT, Ribnicky DM. Modulation of insulin action by botanical therapeutics. Obes Weight Manag 2009;5(6):277-281. Review, no PMCID needed. 
  53. Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite 2010 Aug;55(1):37-43.  PMCID: PMC2900484
  54. Kellogg J, Ribnicky D, Wang J, Flint C, Kuhn P, Raskin I, Lila MA. Alaskan wild berry resources and human health under the cloud of climate change. J Agric Food Chem 2010 Apr 14;58(7):3884-3900. PMCID: PMC2850959
  55. Cefalu WT, Stephens J, Ribnicky DM.  Diabetes and Herbal (Botanical) Medicine.  In: Herbal Medicine: Biomolecular and Clinical Aspects, 2nd Edition (a volume in the Oxidative Stress & Disease Series) (Benzie I, Wachtel-Galor S, eds.), Taylor & Francis, Oxford, UK, 2011:405-418. Book chapter, no PMCID needed
  56. Ilic N, Schmidt BM, Poulev A, Raskin I. Toxicological evaluation of grains of paradise (Aframomum melegueta). J Ethnopharmacol 2010 Feb 3;127(2)352-356.  PMCID: PMC3815460
  57. Kheterpal I, Coleman L, Ku G, Wang ZQ, Ribnicky D, Cefalu WT. Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture – a proteomics approach. Phytother Res 2010 Sep;24(9):1278-1284
  58. Wang ZQ, Ribnicky DM, Zhang XH, Zuberi A, Raskin I, Yu U, Cefalu WT. An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KKay mice. J Nutr Biochem 2010 Jan;22(1):71-78. PMCID: PMC4020631


Publications from Funding Period 2
Links to free full-text articles in PubMed Central or through the Journal website are provided when available.

Funding Period 2 (2010-2015)

 

  1. Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite 2010;55:37-43. PMCID: PMC2900484
  2. Kellogg J, Ribnicky D, Wang J, Flint C, Kuhn P, Raskin I, Lila MA. Alaskan wild berry resources and human health under the cloud of climate change. J Agric Food Chem 2010;58:3884-3900. PMCID: PMC2850959
  3. Graziose R., Lila MA, Raskin I. Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Curr Drug Discov Technol 2010;7:2-12. PMCID: PMC3017680
  4. Dey M, Kuhn P, Ribnicky D, Premkumar V, Reuhl K, Raskin I. Dietary phenethylisothiocyanate attenuates bowel inflammation in mice. BMC Chem Biol 2010;10:4. PMCID: PMC2881005
  5. Graf BL, Raskin I, Cefalu WT, Ribnicky DM. Plant-derived therapeutics for the treatment of metabolic syndrome. Curr Opin Investig Drugs 2010;11:1107-1115. PMCID: PMC3755736
  6. Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 2010;140:1764-1768. PMCID: PMC3139238
  7. Kheterpal I, Coleman L, Ku G, Wang ZQ, Ribnicky D, Cefalu WT. Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture – a proteomics approach. Phytother Res 2010;24:1278-1284
  8. Stull AJ1, Galgani JE, Johnson WD, Cefalu WT. The contribution of race and diabetes status to metabolic flexibility in humans. Metabolism. 2010 Sep;59(9):1358-1364.
  9. Watcho P, Stavniichuk R, Ribnicky DM, Raskin I, Obrosova IG. High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L. Mediators Inflamm 2010;2010:268547. PMCID: PMC2852597
  10. Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One 2010;5(1):e8758. PMCID: PMC280745.
  11. Rojo LE, Villano CM, Joseph G, Schmidt B, Shulaev V, Shuman JL, Lila MA, Raskin I. Wound-healing properties of nut oil from Pouteria lucuma. J Cosmet Dermatol 2010;9:185-95. PMCID: PMC4097019
  12. Premkumar V, Dey M, Dorn R, Raskin I. MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of triptolide in ligand-stimulated macrophages. BMC Chem Biol 2010;10:3. doi: 10.1186/1472-6769-10-3. PMCID: PMC2873377.
  13. Ilic N, Schmidt BM, Poulev A, Raskin I. Toxicological evaluation of grains of paradise (Aframomum melegueta). J Ethnopharmacol 2010;127(2):352-356. PMCID: PMC3815460
  14. Gorelick-Feldman J, Cohick W, Raskin I. Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells. Steroids 2010;75:632-637. PMCID: PMC3815456
  15. Wang ZQ, Ribnicky DM, Zhang XH, Zuberi A, Raskin I, Yu U, Cefalu WT. An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KKay mice. J Nutr Biochem 2011;22(1):71-78. PMCID: PMC4020631
  16. Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, Cefalu WT. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem 2011;22:1064-1073. PMCID: PMC3135761
  17. Ilnytska O, Stütz AM, Park-York M, York DA, Ribnicky DM, Zuberi A, Cefalu WT, Argyropoulos G. Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite. Diabetes 2011;60:97-106. PMCID: PMC3012203
  18. Komarnytsky S, Cook A, Raskin I. Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism. Int J Obes (Lond) 2011;35(2):236-243. PMCID: PMC3033477
  19. Cefalu WT, Stephens JM, Ribnicky DM. Diabetes and Herbal (Botanical) Medicine. In: Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Benzie IFF, Wachtel-Galor S, Eds. Boca Raton, CRC Press, 2011, chapter 19. Book chapter.
  20. Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph JA, Ingram DK, Francis J. A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One 2011;6:e24028. PMCID: PMC3174132
  21. Plaisance EP, Greenway FL, Boudreau A, Hill KL, Johnson WD, Krajcik RA, Perrone CE, Orentreich N, Cefalu WT, Gettys TW. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab 2011;96(5):E836-E840. PMCID: PMC3085194
  22. Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. FASEB J 2011;25:3708-3719. PMCID: PMC3177571
  23. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem 2011;54:4057-4066. PMCID: PMC3128125
  24. Watcho P, Stavniichuk R, Tane P, Shevalye H, Maksimchyk Y, Pacher P, Obrosova IG. Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice. Int J Mol Med 2011;27:299-307. PMCID: PMC3044440
  25. Eisenman SW, Poulev A, Struwe L, Raskin I, Ribnicky DM. Qualitative variation of anti-diabetic compounds in different tarragon (Artemisia dracunculus L.) cytotypes. Fitoterapia 2011;82:1062-1074. PMCID: PMC3164315
  26. Roopchand DE, Grace MH, Kuhn P, Cheng DM, Plundrich N, Poulev A, Howell A, Fridlender B, Lila MA, Raskin I. Efficient sorption of polyphenols to soybean flour enables natural fortification of foods. Food Chem 2012;131:1193-1200. PMCID: PMC3742044
  27. Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, Cefalu WT. Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells. Diabetes 2012;61:597-605. PMCID: PMC3282822
  28. Scherp P, Putluri N, LeBlanc GJ, Wang ZQ, Zhang XH, Yu Y, Ribnicky D, Cefalu WT, Kheterpal I. Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L. J Proteomics 2012;75:3199-3210. PMCID: PMC3367113
  29. Buehrer BM, Duffin DJ, Lea-Currie YR, Ribnicky D, Raskin I, Stephens JM, Cefalu WT, Gimble JM. Tools for the identification of bioactives impacting the metabolic syndrome: screening of a botanical extract library using subcutaneous and visceral human adipose-derived stem cell-based assays. J Nutr Biochem 2012;23:519-525. PMCID: PMC3154462
  30. Richard AJ, Amini ZJ, Ribnicky DM, Stephens JM. St. John’s Wort inhibits insulin signaling in murine and human adipocytes. Biochim Biophys Acta 2012;4:557-563. PMCID: PMC3294203
  31. Esposito D, Kizelsztein P, Komarnytsky S, Raskin I. Hypoglycemic effects of brassinosteroid in diet-induced obese mice. Am J Physiol Endocrinol Metab 2012;303:E652-E658. PMCID: PMC3774328
  32. Lila MA, Ribnicky DM, Rojo LE, Rojas-Silva P, Oren A, Havenaar R, Janle EM, Raskin I, Yousef GG, Grace MH. Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. J Agric Food Chem 2012;60:5763-5771. PMCID: PMC3310271
  33. Roopchand D, Rojo LE, Ribnicky D, Raskin I. Anthocyanins and metabolic syndrome. In: Anthocyanins in Health and Disease Prevention. Wallace TC (ed.). CRC Press, Boca Raton, CRC Press, 2012, p. 199-223. Book chapter.
  34. Rojo LE, Roopchand D, Graf B, Cheng D, Ribnicky D, Fridlender B, Raskin I. Role of anthocyanins in skin aging and UV-induced skin damage. In: Anthocyanins in Health and Disease Prevention. Wallace TC, Ed. Boca Raton, CRC Press, 2013, p. 309-322. Book chapter.
  35. Rojo L, Ribnicky D, Logendra S, Poulev A, Rojas P, Kuhn P, Dorn R, Grace M, Lila MA, Raskin I. In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chem 2012;131:387-396.
  36. Lila MA, Ribnicky DM, Rojo LE, Rojas-Silva P, Oren A, Havenaar R, Janle EM, Raskin I, Yousef GG, Grace MH. Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. J Agric Food Chem. 2012 Jun 13;60(23):5763-5771. PMCID: PMC3310271
  37. Cheng DM, Kuhn P, Poulev A, Rojo LE, Lila MA, Raskin I. In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem 2012;135:2994-3002. PMCID: PMC3444749
  38. Wang ZQ, Yu Y, Zhang XH, Floyd ZE, Boudreau A, Lian K, Cefalu WT. Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice. Int J Nanomedicine 2012;7:2999-3012. PMCID: PMC3390996
  39. Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I. Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacol Res 2013;68:59-67. PMCID: PMC3833590
  40. Roopchand DE, Krueger CG, Moskal K, Fridlender B, Lila MA, Raskin I. Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols. Food Chem 2013;141:3664-3669. PMCID: PMC3815467
  41. Obanda DN, Cefalu WT. Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells. J Nutr Biochem 2013;24:1529-1537.
  42. Kirk-Ballard H, Wang ZQ, Acharya P, Zhang XH, Yu Y, Kilroy G, Ribnicky D, Cefalu WT, Floyd ZE. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One 2013;8:e57112. PMCID: PMC3577785
  43. Wang ZQ, Zhang XH, Yu Y, Tipton RC, Raskin I, Ribnicky D, Johnson W, Cefalu WT. Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. Metabolism 2013;62:1239-1249. PMCID: PMC3838888
  44. Elks CM, Francis J, Stull AJ, Cefalu WT, Shukitt-Hale B, Ingram D. Overview of the health properties of blueberries. In: Bioactives in Fruit: Health Properties and Functional Food. Skinner J, Hunter D, Eds. Hoboken, Wiley-Blackwell, 2013, p. 251-271. Book chapter.
  45. Ingram DK, Elks CM, Davenport GM, Roth GS. Potential health benefits of avocados. In: Bioactives in Fruit: Health Properties and Functional Foods. Skinner J, Hunter D, Eds. Hoboken, Wiley-Blackwell, 2013, p. 337-352. Book chapter.
  46. Verpeut JL, Walters AL, Bello NT. Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity. Nutr Res 2013;33:503-512. PMCID: PMC3808124
  47. Maestre R, Douglass JD, Kodukula S, Medina I, Storch J. Alterations in the intestinal assimilation of oxidized PUFAs are ameliorated by a polyphenol-rich grape seed extract in an in vitro model and Caco-2 cells. J Nutr 2013;143:295-301. PMCID: PMC3713019
  48. Bryant SK, Waldrop GL, Gilman SD. A capillary electrophoretic assay for acetyl coenzyme A carboxylase. Anal Biochem 2013;437:32-38. PMCID: PMC3627828
  49. Esposito D, Rathinasabapathy T, Schmidt B, Shakarjian MP, Komarnytsky S, Raskin I. Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair Regen 2013;21:688-696. PMCID: PMC3775972
  50. Richard AJ, Amini-Vaughan Z, Ribnicky DM, Stephens JM. Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes. Evid Based Complement Alternat Med 2013:549750. PMCID: PMC3745873
  51. Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I. Effects of pregnane glycosides on food intake depend on stimulation of melanocortin pathway and BDNF in animal model. J Agric Food Chem 2013;61:1841-1849. PMCID: PMC3805381
  52. Komarnytsky S, Esposito D, Poulev A, Raskin I. Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. J Cell Physiol 2013;228:1120-1126. PMCID: PMC3796370
  53. Yu Y, Zhang XH, Ebersole B, Ribnicky D, Wang ZQ. Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice. Sci Rep 2013;3:3142. PMCID: PMC3912441
  54. Ribnicky DM, Roopchand DE, Oren A, Grace M, Poulev A, Lila MA, Havenaar R, Raskin I. Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chem 2014;142:349-357. PMCID: PMC4072317
  55. Cefalu WT. Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition. J Clin Invest 2014 Feb 3;124(2):485-7. PMCID: PMC3904638
  56. Malina A, Bryant SK, Chang SH, Waldrop GL, Gilman SD. Capillary electrophoresis-based assay of phosphofructokinase-1. Anal Biochem 2014;447:1-5. PMCID: PMC3943981
  57. Vandanmagsar B, Haynie KR, Wicks SE, Bermudez EM, Mendoza TM, Ribnicky D, Cefalu WT, Mynatt RL. Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture. Diabetes Obes Metab 2014 Aug;16(8):728-738. PMCID: PMC4107009
  58. Henagan TM, Lenard NR, Gettys TW, Stewart LK. Dietary quercetin supplementation in mice increases skeletal muscle PGC1α expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One 2014;9:e89365. PMCID: PMC3931728
  59. Waterman C, Cheng DM, Rojas-Silva P, Poulev A, Dreifus J, Lila MA, Raskin I. Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 2014 Jul;103:114-122. PMCID: PMC4071966
  60. Cefalu WT, Floyd ZE, Ribnicky DM, Stephens JM. Botanicals and translational medicine: A paradigm shift in research approach. Nutrition 2014;30(7-8 Suppl):S1-S3.
  61. Boudreau A, Cheng DM, Ruiz C, Ribnicky DM, Allain L, Brassieur CR, Turnipseed DP, Cefalu WT, Floyd ZE. Screening native botanicals for bioactivity: An interdisciplinary approach. Nutrition 2014;30(7-8 Suppl):S11-S16. PMCID: PMC4082803
  62. Wicks SE, Taylor CM, Luo M, Blanchard IV E, Ribnicky DM, Cefalu WT, Mynatt RL, Welsh DA. Artemisia supplementation differentially affects the mucosal and luminal ileal microbiota of diet-induced obese mice. Nutrition 2014;30(7-8 Suppl):S26-S30.
  63. Vance KM, Ribnicky DM, Hermann GE, Rogers RC. St. John’s Wort enhances the synaptic activity of the nucleus of the solitary tract. Nutrition 2014;30(7-8 Suppl):S37-S42. PMCID: PMC4128486
  64. Rood JC, Schwarz J-M, Gettys TW, Mynatt RL, Mendoza T, Johnson WD, Cefalu WT. The effects of Artemisia species on de novo lipogenesis in vivo. Nutrition 2014;30(7-8 Suppl):S17-S20. PMCID: PMC4120075
  65. Obanda DN, Ribnicky DM, Raskin I, Cefalu WT. Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells. Nutrition 2014;30(7-8 Suppl):S59-S66. PMCID: PMC4082801
  66. Ribnicky DM, Roopchand DE, Poulev A, Kuhn P, Cefalu WT, Raskin I. Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice. Nutrition 2014;30(7-8 Suppl):S4-S10.  PMCID: PMC4116120
  67. Kirk-Ballard H, Kilroy G, Day BC, Wang ZQ, Ribnicky DM, Cefalu WT, Floyd ZE. An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: Potential role in the treatment of sarcopenic obesity. Nutrition 2014;30(7-8 Suppl):S21-S25. PMCID: PMC4082804
  68. Kheterpal I, Scherp P, Kelley L, Wang Z, Johnson WD, Ribnicky DM, Cefalu WT. Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation. Nutrition 2014;30(7-8 Suppl):S43-S51.
  69. Cheng DM, Pogrebnyak N, Kuhn P, Krueger CG, Johnson WD, Raskin I. Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. PLoS One 2014;9:e91571. doi: 10.1371/journal.pone.0091571. PMCID: PMC3956610
  70. Cheng DM, Pogrebnyak N, Kuhn P, Poulev A, Waterman C, Rojas-Silva P, Johnson WD, Raskin I. Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet induced obese C57BL/6 mice. Nutrition 2014 Jul-Aug;30(7-8 Suppl):S52-S58.  PMCID: PMC4082798
  71. Graf BL, Poulev A, Kuhn P, Grace M, Lila MA, Raskin I. Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chem 2014 Nov 15;163:178-185. PMCID: PMC4116738
  72. Richard AJ, Burris TP, Sanchez-Infantes D, Wang Y, Ribnicky DM, Stephens JS. Artemisia extracts activate PPARγ, promote adipogenesis, and enhance insulin sensitivity in adipose tissue of obese mice. Nutrition 2014;30(7-8 Suppl):S31-S36. PMCID: PMC4082805
  73. Richard AJ, Fuller S, Fedorcenco V, Beyl R, Burris TP, Mynatt RL, Ribnicky DM, Stephens JM. Artemisia scoparia enhances adipocyte development and endocrine function in vitro and enhances insulin action in vivo. PLoS One 2014 Jun 10;9(6):e98897. PMCID: PMC4051605 
  74. Fuller S, Richard AJ, Ribnicky DM, Mynatt RL, Beyl R, Stephens JM. St. John's Wort has metabolically favorable effects on adipocytes in vivo. J Evid Based Complementary Altern Med 2014;2014:862575. PMCID: PMC4054923
  75. Elks CM, Terrebonne JD, Ingram DK, Stephens JM.  Blueberries improve glucose tolerance and lipid handling without affecting body composition in obese postmenopausal mice.  Obesity (Silver Spring) 2015 Mar; 23(3):573-580.  PMCID: PMC4340720

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Publications from Funding Period 3
Links to free full-text articles in PubMed Central or through the Journal website are provided when available.

Funding Period 3 (2015-2020)

  1. Vance KM, Rogers RC, Hermann GE. PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci. 2015 Jan 14;35(2):776-85. PMCID: PMC4293422

  2. Vance KM, Rogers RC, Hermann GE. NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract. Brain Res. 2015 Jan 21;1595:84-91. PMCID: PMC4330085

  3. Tumer TB, Rojas-Silva P, Poulev A, Raskin I, Waterman C. Direct and indirect antioxidant activity of polyphenol- and isothiocyanate-enriched fractions from Moringa oleifera. J Agric Food Chem. 2015 Feb 11;63(5):1505-13. PMCID: PMC4798254

  4. Elks CM, Terrebonne JD, Ingram DK, Stephens JM. Blueberries improve glucose tolerance without altering body composition in obese postmenopausal mice. Obesity (Silver Spring). 2015 Mar;23(3):573-80. PMCID: PMC4340720

  5. Fuller S, Stephens JM. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr. 2015 Mar;6(2):189-97. PMCID: PMC4352177

  6. Bruce-Keller AJ, Salbaum JM, Luo M, Blanchard E 4th, Taylor CM, Welsh DA, Berthoud HR. Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity. Biol Psychiatry. 2015 Apr 1;77(7):607-15. PMCID: PMC4297748

  7. Stull AJ, Cash KC, Champagne CM, Gupta AK, Boston R, Beyl RA, Johnson WD, Cefalu WT. Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2015 May 27;7(6):4107-23. PMCID: PMC4488775

  8. Waterman C, Rojas-Silva P, Tumer TB, Kuhn P, Richard AJ, Wicks S, Stephens JM, Wang Z, Mynatt R, Cefalu W, Raskin I. Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. Mol Nutr Food Res. 2015 Jun;59(6):1013-24. PMCID: PMC4456298

  9. Obanda DN, Yu Y, Wang ZQ, Cefalu WT. Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle. J Nutr Biochem. 2015 Jul;26(7):687-95. PMCID: PMC4461540

  10. Aggarwal S, Shailendra G, Ribnicky DM, Burk D, Karki N, Qingxia Wang MS. An extract of Artemisia dracunculus L stimulates insulin secretion from β cells, activates AMPK and suppresses inflammation. J Ethnopharmacol. 2015 Jul 21;170:98-105. PMCID: PMC4470741

  11. Roopchand DE, Carmody RN, Kuhn P, Moskal K, Rojas-Silva P, Turnbaugh PJ, Raskin I. Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome. Diabetes. 2015 Aug;64(8):2847-58. PMCID: PMC4512228

  12. Liu AG, Arceneaux KP 3rd, Chu JT, Jacob G Jr, Schreiber AL, Tipton RC, Yu Y, Johnson WD, Greenway FL, Primeaux SD. The effect of caffeine and albuterol on body composition and metabolic rate. Obesity (Silver Spring). 2015 Sep;23(9):1830-5. PMCID: PMC4551658

  13. Johnson WD, Burton JH, Beyl RA, Romer JE. A Simple Chi-Square Statistic for Testing Homogeneity of Zero-Inflated Distributions. Open J Stat. 2015 Oct;5(6):483-493. PMCID: PMC4664523

  14. Cahn A, Raz I, Kleinman Y, Balicer R, Hoshen M, Lieberman N, Brenig N, Del Prato S, Cefalu WT. Clinical Assessment of Individualized Glycemic Goals in Patients With Type 2 Diabetes: Formulation of an Algorithm Based on a Survey Among Leading Worldwide Diabetologists. Diabetes Care. 2015 Dec;38(12):2293-300. PMCID: PMC4657613

  15. Obanda DN, Zhao P, Richard AJ, Ribnicky D, Cefalu WT, Stephens JM. Stinging Nettle (Urtica dioica L) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner. PLoS One. 2016;11(3):e0150252. PMCID: PMC4777364

  16. Graf BL, Rojo LE, Delatorre-Herrera J, Poulev A, Calfio C, Raskin I. Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physico-chemical characteristics. J Sci Food Agric. 2016 Jan 30;96(2):633-43. PMCID: PMC4534356

  17. Johnson WD, Romer JE. Hypothesis Testing of Population Percentiles via the Wald Test with Bootstrap Variance Estimates. Open J Stat. 2016 Feb;6(1):14-24. PMCID: PMC4811631

  18. Rebello CJ, O'Neil CE, Greenway FL. Dietary fiber and satiety: the effects of oats on satiety. Nutr Rev. 2016 Feb;74(2):131-47. PMCID: PMC4757923

  19. Obanda DN, Ribnicky D, Yu Y, Stephens J, Cefalu WT. An extract of Urtica dioica L mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A). Sci Rep. 2016 Feb 26;6:22222. PMCID: PMC4768183

  20. Reiner DJ, Mietlicki-Baase EG, McGrath LE, Zimmer DJ, Bence KK, Sousa GL, Konanur VR, Krawczyk J, Burk DH, Kanoski SE, Hermann GE, Rogers RC, Hayes MR. Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance. J Neurosci. 2016 Mar 23;36(12):3531-40. PMCID: PMC4804010

  21. Cheng DM, Roopchand DE, Poulev A, Kuhn P, Armas I, Johnson WD, Oren A, Ribnicky D, Zelzion E, Bhattacharya D, Raskin I. High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet-induced obese mice. Mol Nutr Food Res. 2016 Nov;60(11):2367-2378. PMCID: PMC5240636

  22. Armas I, Pogrebnyak N, Raskin I. A rapid and efficient in vitro regeneration system for lettuce (Lactuca sativa L.). Plant Methods. 2017;13:58. PMCID: PMC5520378

  23. Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I. Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract. PLoS One. 2017 Aug 8;12(8):e0182658. PMCID: PMC5549737

  24. Kim Y, Wu AG, Jaja-Chimedza A, Graf BL, Waterman C, Verzi MP, Raskin I. Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice. PLoS One. 2017 Sep 18;12(9):e0184709. PMCID: PMC5602518

  25. Knott EJ, Richard AJ, Mynatt RL, Ribnicky D, Stephens JM, Bruce-Keller A. Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Scientific Reports 2017 Oct 6;7(1):12770. PMCID: PMC5630574

  26. Rebello CJ, Greenway FL, Johnson WD, Ribnicky D, Poulev A, Stadler K, Coulter AA. Fucoxanthin and its metabolite fucoxanthinol do not induce browning in human adipocytes. J Agric Food Chem. 2017 Dec 20;65(50):10915-10924.  PMCID:  PMC5751931

  27. Yu Y, Mendoza TM, Ribnicky DM, Poulev A, Noland RC, Mynatt RL, Raskin I, Cefalu WT, Floyd ZE. An extract of Russian tarragon prevents obesity-related ectopic lipid accumulation. Mol Nutr Food Res. 2018 Apr;62(8):e1700856. PMCID: PMC5929974

  28. Boudreau A, Fuller S, Ribnicky DM, Richard AJ, Stephens JM. Groundsel bush (Baccharis halimifolia) extract promotes adipocyte differentiation in vitro and increases adiponectin expression in mature adipocytes. Biology 2018 Mar 25;7(2). PMCID: PMC5859957

  29. Losso JN, Finley JW, Karki N, Liu AG, Prudente A, Tipton R, Yu Y, Greenway FL. Pilot study of the tart cherry juice for the treatment of insomnia and investigation of  mechanisms.  Am J  Ther.  2018 Mar/Apr;25(2):e194-e201. PMCID:  PMC5617749

  30. Forney LA, Lenard NR, Stewart LK, Henagan TM. Dietary quercetin attenuates adipose tissue expansion and inflammation and alters adipocyte morphology in a tissue-specific manner. Int J Mol Sci. 2018 Mar 17;19(3) pii: E895. PMCID: PMC5877756

  31. Wang J, Fernández AE, Tiano S, Huang J, Floyd ZE, Poulev A, Ribnicky DM, Pasinetti GM. PMI5011 promotes psychological resilience in a mouse model of depression. Oxid Med Cell Longev. 2018 May 13;2018:7418681. PMCID: PMC5971253

  32. Zhang L, Carmody RN, Kalariya HM, Duran RM, Moskal K, Poulev A, Kuhn P, Tveter KM, Turnbaugh, PJ, Raskin I, Roopchand DE. Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health. J Nutr Biochem. 2018 Jun;56:142-151. PMCID: PMC5971143

  33. Kim Y, Jaja-Chimedza A, Raskin I. Toxicological evaluation of isothiocyanate-enriched moringa seed extract. Toxicol Rep. 2018 Mar 6;5:418-426. PMCID: PMC5977371

  34. Jaja-Chimedza A, Zhang L, Wolff K, Graf BL, Kuhn P, Moskal K, Carmouche R, Newman S, Salbaum JM, Raskin I. Isothiocyanate-enriched moringa (Moringa oleifera) seed extract mitigates the effects of high fat diet and changes in gut microbiome. J Funct Foods. 2018 Aug;47:376-385. PMCID: PMC6435304

  35. Fuller, S. Yu Y, Mendoza TM, Ribnicky DM, Cefalu WT, Floyd ZE.  Potential adverse effects of botanical supplementation in high-fat-fed female mice. Biol Sex Differ. 2018 Sep 12;9(1):41. PMCID: PMC6134698

  36. Boudreau A, Richard AJ, Burrell JA, King WT, Dunn R, Schwarz JM, Ribnicky DM, Rood J, Salbaum JM, Stephens JM. An ethanolic extract of Artemisia scoparia inhibits lipolysis in vivo and has antilipolytic effects on murine adipocytes in vitro. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1053-E1061. PMCID: PMC6293162

  37. Skubel SA, Dushenkov V, Graf BL, Niu Q, Poulev A, Kalariya HM, Foxcroft LC, Raskin I. Rapid, field-deployable method for collecting and preserving plant metabolome for biochemical and functional characterization. PLoS One. 2018;13(9):e0203569. PMCID: PMC6126852

  38. Allerton TD, Proctor TN, Stephens JM, Dugas TR, Spielma, G, Irving BA. l-Citrulline supplementation: Impact on cardiometabolic health. Nutrients. 2018;19;10(7). PMCID: PMC6073798

  39. Rebello CJ, Greenway FL, Lau FH, Yin Y, Stephens JM, Johnson WD, Coulter AA.  Naringenin Promotes Thermogenic Gene Expression in Human White Adipocytes. Obesity. 2018;27(1):103-111.  doi: 10.1002/oby.22352. PMCID: PMC6309263

  40. Kuhn P, Kalariya HM, Poulev A, Ribnicky DM, Jaja-Chimedza A, Roopchand DE, Raskin I. (2018). Grape polyphenols reduce gut-localized reactive oxygen species associated with the development of metabolic syndrome in mice. PLoS One. 2018;13(10):e0198716. doi: 10.1371/journal.pone.0198716. PMCID: PMC6181265

  41. Jaja-Chimedza A, Zhang L, Wolff K, Graf BL, Kuhn P, Moskal K, Carmouche R, Newman S, Salbaum JM, Raskin I. A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome. J Funct Foods. 2018;47:376-385. PMCID: PMC6435304

  42. Gurdon C, Poulev A, Armas I, Satorov S, Tsai M, Raskin I. Genetic and phytochemical characterization of lettuce flavonoid biosynthesis mutants. Sci Rep. 2019 Mar 1;9(1):3305. PMCID: PMC6397293

  43. Boudreau A, Poulev A, Ribnicky DM, Raskin I, Rathinasabapathy T, Richard AJ, Stephens JM. Distinct fractions of an Artemisia scoparia extract contain compounds with novel adipogenic bioactivity. Front Nutr. 2019 8;18. PMCID: PMC6418310

  44. Poulev A, Heckman JR, Raskin I, Belanger FC. (2019). Tricin levels and expression of flavonoid biosynthetic genes in developing grains of purple and brown pericarp rice. PeerJ. 2019;7:e6477. doi: 10.7717/peerj.6477. PMCID: PMC6383554

  45. Cheng D, Gao L, Su S, Sargsyan D, Wu R, Raskin I, Kong AN. Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy. AAPS J. 2019;21(2):31. doi: 10.1208/s12248-019-0301-6. PMCID: PMC6647035

  46. Yu Y, Simmler C, Kuhn P, Poulev A, Raskin R, Cefalu WT, Ribnicky DM, Floyd ZE, Pauli GF. The DESIGNER approach helps deciphering the hypoglycemic bioactive principle of Artemisia dracunculus. J Nat Prod. In review.

  47. Fuller S, Yu Y, Allerton T, Mendoza TM, Ribnicky DM, Floyd ZE. High fat, high sucrose diet-fed female mice develop metabolic dysfunction that is not ameliorated by botanical supplementation. Submitted to Journal of Nutrition.

  48. Gurdon C, Poulev A, Armas I, Raskin I. Insertion of a CACTA-family transposon in the ANTHOCYANIDIN SYNTHASE 5’UTR results in the loss of anthocyanin accumulation in lettuce. In preparation.

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