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The Animal Research Core Return to Cores
All animal studies performed as part of the Botanical Research Center (BRC) are performed in the Comparative Biology centralized facility of the Pennington Biomedical Research Center. The Animal Research Core (ARC) functions as an in vivo phenotyping and investigative arm of the BRC to provide detailed assessments of phenotypes influenced by botanical action.  The ARC interacts with all components of the BRC and plays a central role in the controlled and rigorous phenotypic profiling of mouse models of metabolic syndrome. All three botanicals from the three core projects converge in the Animal Core. 

The ongoing goals of the ARC are to determine the mechanism of action of the specific botanicals of interest to investigators as part of the BRC in the treatment of metabolic syndrome, help the BRC identify bioactive phytochemicals using in vivo phenotyping strategies, and utilize the mouse classical and molecular genetic expertise of the ARC to identify and characterize modifier genes that influence botanical action.  These goals will be met by the following specific aims:

  • To work closely with the Botanical Research Core (BRC) Program Director, leaders of Research Projects and the Botanical Core to assist in the experimental design and execution of the animal research phase of the individual projects. ARC investigators work with the Botanical Research Core (BRC) and leaders of Research Projects to assist in the experimental design and execute the animal research phase of the individual projects.
  • To perform detailed in vivo metabolic profiling using botanicals of interest to investigators of the BRC.  The data will be used to generate and/or support new hypotheses about the potential mechanism(s) of botanical action and future Pilot Research proposals submitted to the BRC.  The ARC will assist investigators in the execution of any animal research phase of Pilot projects. 
  • As a research component of the ARC, to develop a genetic model of botanical action to complement the proposed candidate gene, microarray- and proteomic-based strategies being pursued by the BRC investigators. Mapping of the genomic regions containing polymorphic phytogenomic genes will assist in the identification of candidate genes and will complement the proposed candidate gene, microarray- and proteomic-based strategies being pursued by other BRC investigators.
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